The brain is 70% fat, which chiefly serves to insulate neurons. Fat is also the primary component of cell membranes. Changing the proportion of saturated to unsaturated fats in the diet changes the fat composition in these membranes. This could conceivably change the membrane permeability, which controls the transport of everything from glucose, signaling proteins, and hormones to bacteria, viruses, and tumor-causing agents into and out of the cell. The relative saturation of fats in the diet could also influence cellular aging as well as the clotting ability of blood cells.
there is a growing body of data that is questioning the validity of health benefit claims associated with a lowfat, high fiber diet. for example, while there seems to be no question that carrying extra weight negatively impacts cholesterol... treating your cholesterol with a lowfat regime isn't necessarily the most healthful option
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